CAS Name: 4-Chloro-2-methylbenzenamine Synonyms: 2-Amino-5-chlorotoluene; 3-chloro-6-aminotoluene; 4-chloro-2- methylaniline; 4-chloro-6-methylaniline; (4-chloro-2-methylphenyl)amine; 4-chloro-2-toluidine; 4-chloro-ortho-toluidine; 5-chloro-2-aminotoluene; para-chloro-ortho-toluidine; 2-methyl-4-chloroaniline; 2-methyl-4- chlorobenzeneamine
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Macromolecular binding and metabolism of the carcinogen 4-chloro-2-methylaniline.
Biochemical investigations relating to the mechanism of action and mechanism of activation have been made for the carcinogen, 4-chloro-2-methylaniline. Radioactivity from 4-chloro-2-[methyl-14C]methylaniline became extensively bound to protein, DNA, and RNA of rat liver, but macromolecules of some of the other tissues examined contained little radioactivity. Enzymatic activity dependent upon re...
متن کاملChloromethylmuconolactones as critical metabolites in the degradation of chloromethylcatechols: recalcitrance of 2-chlorotoluene.
To elucidate possible reasons for the recalcitrance of 2-chlorotoluene, the metabolism of chloromethylcatechols, formed after dioxygenation and dehydrogenation by Ralstonia sp. strain PS12 tetrachlorobenzene dioxygenase and chlorobenzene dihydrodiol dehydrogenase, was monitored using chlorocatechol dioxygenases and chloromuconate cycloisomerases partly purified from Ralstonia sp. strain PS12 an...
متن کاملDegradation of p-chlorotoluene by a mutant of Pseudomonas sp. strain JS6.
Pseudomonas sp. strain JS6 grows on chlorobenzene, p-dichlorobenzene, or toluene as a sole source of carbon and energy. It does not grow on p-chlorotoluene (p-CT). Growth on glucose in the presence of p-CT resulted in the accumulation of 4-chloro-2,3-dihydroxy-1-methylbenzene (3-chloro-6-methylcatechol), 4-chloro-2,3-dihydroxy-1-methylcyclohexa-4,6-diene (p-CT dihydrodiol), and 2-methyl-4-carbo...
متن کاملSynthesis of some new substituted azetidinonyl and thiazolidinonyl quinazolon-4(3H)-ones as potential non-steroidal anti-inflammatory and analgesic agents
A series of 2-(5-(6-Bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)-4H-1,2,4-triazole-3-ylthio)-N-(substituted benzylidene) acetohydrazides (5a-5l) have been synthesized via condensation of 2-(5-(6-Bromo-2-methyl-4-oxaquinazolin-3 (4H)-yl)-4H-1,2,4-triazole-3-ylthio)acetohydrazide (4) with different aromatic aldehydes. Cycloaddition of thioglycolic acid with 5a-5l yielded 2-[5-(6-Bromo-2-methyl-4-oxoq...
متن کاملBacterial hydroxylation of pyrazon compounds.
Abbreviations: Pyrazon, 5-amino-4-chloro-2-phenyl-3 (2H) pyridazinone; o-methyl-pyrazon, 5-amino-4-chloro-2(2-methylphenyl)-3(2H)-pyridazinone; m-methyl-pyrazon, 5-aminoj4-chloro-2(3-methylphenyl) 43 (2H) -pyridazinone; p-methyl-pyrazon, 5-amino-4-chloro-2(4-methylphenyl) -3 (2H) pyridazinone. Requests for reprints should be sent to Prof. Dr. F. Lingens, Institut für Mikrobiologie und Molekular...
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